منابع مشابه
DDAH says NO to ADMA.
Endothelium-derived nitric oxide (NO) is vasoprotective, as it enhances endothelial cell survival and proliferation, inhibits the excessive proliferation of vascular smooth muscle cells, and suppresses the adhesion of platelets and inflammatory cells to the vessel wall.1 Substantial evidence from preclinical studies and human research indicates that impairment of the endothelial NO synthase (NO...
متن کاملPDE5 says NO to cGMP
A protease inhibitor unsticks cells AI-1 is unique among protease inhibitors because it binds to the matrix protein vitronectin (VN). PAI-1 binding blocks VN's binding site for the cell surface receptor uPAR and for integrin family members. Czekay et al. (page 781) now show that PAI-1 is also able to detach cells through a less direct approach. Unlike the direct competition method, PAI-1 also d...
متن کاملFolic acid says NO to vascular diseases.
OBJECTIVES The possible link between folic acid or folate and tetrahydrobiopterin (H(4)B), vitamin C, polyunsaturated fatty acids (PUFAs), and nitric oxide (NO), which may explain the beneficial actions of these nutrients in various vascular conditions, was investigated. METHODS The literature pertaining to the actions of folic acid/folate, H(4)B, vitamin C, PUFAs, and NO was reviewed. RESU...
متن کاملInsulin says NO to cardiovascular disease.
It is well recognized that insulin resistance found in patients with type 2 diabetes and obesity is a major risk factor for cardiovascular disease. Since its discovery in the 1920s, insulin has been used as an essential therapeutic agent in diabetes for blood glucose management. Recent studies demonstrate that insulin signalling is essential for normal cardiovascular function, and lack of it (i...
متن کاملWhen the patient says "no".
This is a report about S.K., a woman who suffered from cancer during the last 8 years of her life, but continued to exercise her free will, and to participate actively in her medical management until she died. This was only possible through an empowering and transparent patient–doctor relationship. Doctors and patients are often faced with the dilemma of undergoing management options which are ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2011
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1935iti2